CPLM: Compendium of Protein Lysine Modifications
|The CUCKOO Workgroup|
|CPLA is a compendium database for lysine acetylated substrates. It contains 3,311 unique protein entries with 7,151 experimentally identified lysine acetylation sites, that were manually collected from the scientific literature. The regulatory roles of lysine acetylation were statistically analyzed with the gene Ontology (GO) and InterPro annotations.
Combinations with protein-protein interaction information are systematically discovered a potential human lysine acetylation network (HLAN) among histone acetyltransferases (HATs), substrates and histone deacetylases (HDACs). There are 1862 triplet relationships of HAT-substrate-HDAC retrieved from the HLAN, at least 13 of which were previously experimentally verified.
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